Ca sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries
نویسندگان
چکیده
Juan Carlos Robles, Michael Sturek, Janet L. Parker, and Cristine L. Heaps Michael E. DeBakey Institute for Comparative Cardiovascular Science and Biomedical Devices and Departments of Veterinary Physiology and Pharmacology and Small Animal Clinical Sciences, Texas A&M University, College Station; and Department of Systems Biology and Translational Medicine and Cardiovascular Research Institute, The Texas A&M University System Health Science Center, College Station, Texas; and Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana
منابع مشابه
Ca2+ sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries.
Exercise training enhances endothelium-dependent coronary vasodilatation, improving perfusion and contractile function of collateral-dependent myocardium. Paradoxically, studies from our laboratory have revealed increased Ca(2+)-dependent basal active tone in collateral-dependent arteries of exercise-trained pigs. In this study, we tested the hypothesis that exercise training enhances agonist-m...
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We previously reported that canine collateral-dependent coronary arteries exhibit impaired relaxation to adenosine but not sodium nitroprusside. In contrast, exercise training enhances adenosine sensitivity of normal porcine coronary arteries. These results stimulated the hypothesis that chronic coronary occlusion and exercise training produce differential effects on cAMP- versus cGMP-mediated ...
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Exercise training of coronary artery disease patients is of considerable interest, since it has been shown to improve vascular function and, thereby, enhance blood flow into compromised myocardial regions. However, the mechanisms underlying exercise-induced improvements in vascular function have not been fully elucidated. We tested the hypothesis that exercise training increases the contributio...
متن کاملAltered calcium sensitivity contributes to enhanced contractility of collateral-dependent coronary arteries.
Coronary arteries distal to chronic occlusion exhibit enhanced vasoconstriction and impaired relaxation compared with nonoccluded arteries. In this study, we tested the hypotheses that an increase in peak Ca(2+) channel current density and/or increased Ca(2+) sensitivity contributes to altered contractility in collateral-dependent coronary arteries. Ameroid occluders were surgically placed arou...
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تاریخ انتشار 2011